Meniere's disease might be an autoimmune condition?

Discussion in 'Your Living Room' started by Vicki615, May 9, 2014.

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  1. Vicki615

    Vicki615 New Member

    WOW A statement here blew me away..I made it bold

    http://www.ncbi.nlm.nih.gov/pubmed/22306860
    Autoimmun Rev. 2012 Aug;11(10):731-8. doi: 10.1016/j.autrev.2012.01.004. Epub 2012 Jan 28.

    Meniere's disease might be an autoimmune condition?

    Greco A1, Gallo A, Fusconi M, Marinelli C, Macri GF, de Vincentiis M.
    Author information
    Abstract

    OBJECTIVES:

    To review our current knowledge of the pathogenesis of Meniere's disease, including viral infection and immune system-mediated mechanisms, and to discuss the pathogenesis as it relates to pharmacotherapy.

    SYSTEMATIC REVIEW METHODOLOGY:

    Relevant publications on the aetiopathogenesis, molecular biology, genetics and histopathology of Meniere's disease from 1861 to 2011 were analysed.

    RESULTS AND CONCLUSIONS:

    Meniere's disease is characterised by intermittent episodes of vertigo, fluctuating sensorineural hearing loss, tinnitus, and aural pressure. The aetiology and pathogenesis remain unknown. Proposed theories of causation include viral infections and immune system-mediated mechanisms. The immune response in Meniere's disease is focused on inner ear antigens. Approximately one-third of Meniere's disease cases seem to be of an autoimmune origin although the immunological mechanisms involved are not clear. The diagnosis of autoimmune inner ear disease is based either on clinical criteria or on a positive response to steroids. The antiviral approach has virtually eliminated the use of various surgical methods used in the past. Steroid responsiveness is high, and with prompt treatment, inner ear damage may be reversible. The administration of etanercept improves or stabilises symptoms in treated patients. Treatment of antiphospholipid syndrome can be directed toward preventing thromboembolic events by using antithrombotic medications. Only warfarin has been shown to be effective. Gene therapy can be used to transfer genetic material into inner ear cells using viral vectors and to protect, rescue, and even regenerate hair cells of the inner ear.

    Copyright © 2012 Elsevier B.V. All rights reserved.


    PMID: 22306860 [PubMed - indexed for MEDLINE]
     
  2. Vicki615

    Vicki615 New Member

    "Gene therapy can be used to transfer genetic material into inner ear cells using viral vectors and to protect, rescue, and even regenerate hair cells of the inner ear."

    Anyone heard of gene therapy for the inner ear? Very interesting
     
  3. jimmykicker

    jimmykicker New Member

    Sure is...mine I believe will never be the same...If I could hear like I did before this garbage? Woah...

    Interesting how they are talking about the relevance of antivirals and there is a connection! Bout time.
     
  4. Vicki615

    Vicki615 New Member

    Yup and Dr Gacek said same thing that the AVs virtually eliminated the need for surgery in his practice. I should email him this abstract he might like to see it if he already hasn't.
     

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