Hilary A. Brodie, MD, PhD

Chair of Otolaryngology; Professor
Otolaryngology (ENT/Ears, Nose, Throat)
Otology/Neurotology
Surgery - Head and Neck, Otolaryngology
Cancer

Clinical Interests
Dr. Brodie has a subspecialty practice in otology and neurotology. His clinical focus is in hearing loss and various diseases affecting the middle and inner ears. Together with Dr. Karen Doyle, he works with a team of audiologists, speech pathologists and physical therapists to provide comprehensive programs in cochlear implantation and in the treatment of vestibular disorders.

Research/Academic Interests
Dr. Brodie is engaged in research related to understanding the underlying mechanisms of a disease called labyrinthitis ossificans, in which new bone forms in the inner ear following diseases such as meningitis, skull fractures, and various inflammatory diseases.

The significance of this research involves future cochlear implantation. If a child is deafened by meningitis and the cochlea fills with new bone, insertion of a cochlear implant is hindered. Understanding the mechanisms of bone deposition will hopefully allow for inhibition of the process and thereby maintain a patent cochlea.

Board Certifications
American Board of Otolaryngology, Certified, 1991

Undergraduate School
B.S., UC Santa Barbara, Santa Barbara, California, 1977

Medical School
M.D., University of Colorado School of Medicine, Denver, Colorado, 1983

Other School
Ph.D., UC Davis School of Medicine, Sacramento, California, 1991

Internship
Presbyterian Hospital, Denver, Colorado, 1984

Residency
University of California, Davis Medical Center, Sacramento, California, 1991-92

Fellowship
University of California, Davis Medical Center, Los Angeles, California, 1992

Select Recent Publications
Tanigawa T, Tanaka H, Hayashi K, Nakayama M, Iwasaki S, Banno S, Takumida M, Brodie H, Inafuku S. Effects of hydrogen peroxide on vestibular hair cells in the guinea pig: Importance of cell membrane impairment preceding cell death. Acta Oto-Laryngologica, 1-7, 2008.

Yeung AH, Tinling SP, Brodie HA. Inhibition of post-meningitic cochlear injury with cerebrospinal fluid irrigation. Otolaryngology-Head and Neck Surgery 134(2):214-24, 2006.

Brodie HA, Yeung AH. Labyrinthitis ossificans. E-medicine, 2006.

Aminpour S, Tinling SP, Brodie HA. Role of tumor necrosis factor alpha (TNF-a) in sensorineural hearing loss following bacterial meningitis. Otology & Neurotology 26(4):602-609, July 2005.

Tinling SP, Nabili VN, Brodie HA. Fine structure histopathology of labyrinthitis ossificans in the gerbil model. Annals of Otology, Rhinology and Laryngology 114(2):161-166, 2005.

Ge N, Brodie SA, Tinling SP, Brodie HA. The effects of superoxide dismutase in gerbils with bacterial meningitis. Otolaryngology Head Neck Surgery 131(5):563-72, November 2004.

Tinling SP, Colton J, Brodie HA. Location and timing of initial osteoid deposition in postmeningitic labyrinthitis ossificans determined by multiple fluorescent labels. The Laryngoscope 114:675-680, April 2004.

Mhatre AM, Kim Y, Brodie HA, Lalwani AK. Macrothrombocytopenia and progressive deafness is due to a mutation in MYH9. Otology & Neurotology 24:205-209, March 2003.

Buckmiller, L.M., H.A. Brodie, K.J. Doyle and W.R. Nemzek. Choristoma of the middle ear: A component of a new syndrome? Otology Neurotology 22 (3):363-368, May 2001.

Nemzek, W.R., H.A. Brodie, S.T. Hecht, B.W. Chong, C.J. Babcook and J.A. Seibert. MR, CT, and plain film imaging of the developing skull base in fetal specimens. American Journal of Neuroradiology 21:1699-1706, October 2000.

DeSautel, M.G. and H.A. Brodie. The effects of decomplementation in the development of labyrinthitis ossificans in gerbils. Laryngoscope 109:1674- 1678, October 1999.

Nabili, V., H.A. Brodie, N.I. Neverov and S.P. Tinling. Chronology of labyrinthitis ossificans induced by streptococcus pneumoniae meningitis. Laryngoscope 109:931-935, June 1999.

Brodie HA, Thompson TC, Vassilian L, Lee BN. Induction of labyrinthitis ossificans after pneumococcal meningitis: An animal model. Otolaryngology-Head and Neck Surgery 118(1):15-21, January 1998.

Brodie HA. Prophylactic antibiotics for post traumatic cerebrospinal fluid fistulae. A Meta-analysis. Archives of Otolaryngology-Head and Neck Surgery 123:749-752, July 1997.

Brodie, H.A. and T.C. Thompson. Management of complications from 820 temporal bone fractures. American Journal of Otology 18:188-197, March 1997.