A lot of the current research is focusing on an immune system dysfunction as the cause of Meniere's and how the ES has an immune system (see one of my recent posts) but I found some older abstracts that show that the ES is part of the MALT and how an infection of one organ of the MALT can be recirculated to the ES. Kinda reminds me of he who cannot be mentioned :X The endolymphatic sac receives antigenetic information from the organs of the mucosa-associated lymphatic system. Abstract http://informahealthcare.com/doi/abs/10.1080/00016489850183403 The endolymphatic sac holds the entire arrangement of immunocompetent cells and functions as an immunological potent control organ for the inner ear. The evidence of secretory immunoglobulin A and other features of lymphocyte subtypes characterizes the endolymphatic sac as an organ of the mucosa-associated lymphatic system (MALT). In this system a permanent recirculation of sensitized memory lymphocytes from one organ to the other has been demonstrated experimentally as serving to dispose memory lymphocytes after renewed antigenetic stimulus. The aim of this study was to prove the possible recirculation of antigen-sensitized lymphocytes to the endolymphatic sac after antigenic stimulus of another part of the mucosa-associated lymphatic system. The results are evidence that the endolymphatic sac is provided with immunocompetent cells which derive from the lymphatic tissue of the nasopharynx. While the origin of immunocompetent cells in the endolymphatic sac still remains uncertain, this study underlines the role of lympho-epithelial tissue of the nasopharynx as a possible cell source for the endolymphatic sac. The results might explain the altered or disturbed function of the endolymphatic sac as a possible cause of certain inner ear diseases. http://www.ncbi.nlm.nih.gov/pubmed/7610890 Abstract Modern immunohistochemical methods allow a functional characterization of the human endolymphatic sac (ES) and its associated cell populations. The currently available immunohistochemical data of the extraosseous part of the human ES support the assumption that the epithelium is metabolically active and capable of both secretion and adsorption. The reactivity of the epithelial cells with antibodies against neuroendocrine antigens imply a paracrine activity of the human ES. Further results provide evidence for a possible role of the human ES in inner ear immune defence and indicate a putative functional relationship of the human ES to the common mucosa-associated immune system (MALT).
LOL nicgmer I think its on the right track too and it kinda explains why that new out patient surgery the Endolymphatic duct blockage that I posted about works and stops vertigo attacks and why just decompressing the sac doesn't work as well.
LOL redwing well its pretty clear its an infection of the MALT from several studies and from *other sources* and new findings that ES is part of the MALT with its own immune stuff going on in there, but how close is a cure, that's what we really need.
I like this one too. A subpopulation of Menière's patients produce antibodies that bind to endolymphatic sac antigens. The endolymphatic sac (ES) has been suggested to serve an important immunological role within the inner ear. Meanwhile, immunological mechanisms have been studied in connection with Meniere's disease. The aim of this study is to look for and recognize antibodies against the ES in the sera of patients with Meniere's disease, using the technique of indirect immunofluorescence. Sera from 50 patients with Meniere's disease, from an animal model of autoimmune inner ear disease, and from healthy controls were tested against ES tissue substrates obtained from guinea pigs. Immunoglobulin deposition in the ES was found in 20 patients (40%) compared with one control (10%). The difference was statistically significant when computing the odds ratios at 95% confidence level. Fluorescein labeling was demonstrated in the ES epithelium in 16% and in the surrounding perisaccular stroma in 24%. Identical immunoreactivity against the ES tissue was depicted in the sera of the experimental animal model. These findings support the possibility of humoral immunological involvement in the Meniere's disease process. Immunological derangement of the ES function could be the first step in a cascade of reactions leading to endolymphatic hydrops and presenting as Meniere's disease. PMID: 8694139 [PubMed - indexed for MEDLINE] http://www.ncbi.nlm.nih.gov/pubmed/8694139
old doesn't mean bad or incorrect heres a new one , I posted this in another thread http://www.ncbi.nlm.nih.gov/m/pubmed/25779626/#fft Gene expression demonstrates an immunological capacity of the human endolymphatic sac. Møller MN, et al. Laryngoscope. 2015. Show full citation Abstract OBJECTIVES/HYPOTHESIS: The purpose of the present study is to explore, demonstrate, and describe the expression of genes related to the innate immune system in the human endolymphatic sac. It is hypothesized that the endolymphatic sac has a significant immunological function in the human inner ear. STUDY DESIGN: DNA microarrays and immunohistochemistry were used for analyses of fresh human endolymphatic-sac tissue samples. METHODS: Twelve tissue samples from the human endolymphatic sac were obtained during translabyrinthine surgery for vestibular schwannoma. Microarray technology was used to investigate tissue sample gene expression using adjacent dura mater as control. The expression of genes specific for the innate immune system was determined and results for selected key molecules verified by immunohistochemistry. RESULTS: A comprehensive overview of expressed genes of the innate immune system was obtained. Multiple key elements of both the cellular and humoral innate immune system were expressed, including Toll-like receptors 4 and 7, as well as beta-defensin and lactoferrin. CONCLUSIONS: The present data provides the first direct evidence of an immunological capacity of the human endolymphatic sac. At the molecular level, the endolymphatic sac is capable of antigen recognition and processing for initiation of an immune response. In addition, potent molecules directly toxic to invading pathogens are expressed by the sac epithelium. This evidence strongly supports the endolymphatic sac as a significant immunological entity of the inner ear. LEVEL OF EVIDENCE: N/A. Laryngoscope, 2015. © 2015 The American Laryngological, Rhinological and Otological Society, Inc.
Thanks for sharing.... no i just say that cause if they just-find it out it could mean that they find a cure soon but about 20 years and nothing happend is not realy hopefull xD . Iam absolutly sure that everthing of that study is correct but if i see some new studys i think they still ignore that fact. But thats only my opinion anyway i hopey they find a cure verry soon for this damm disease