http://www.ncbi.nlm.nih.gov/pubmed/26381561 AJNR Am J Neuroradiol. 2015 Sep 17. [Epub ahead of print] Endolymphatic Hydrops Reversal following Acetazolamide Therapy: Demonstration with Delayed Intravenous Contrast-Enhanced 3D-FLAIR MRI. Sepahdari AR1, Vorasubin N2, Ishiyama G2, Ishiyama A2. Author information 1From the Departments of Radiological Sciences (A.R.S.), Head and Neck Surgery (N.V., A.I.), and Neurology (G.I.), David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California. [email protected]. 2From the Departments of Radiological Sciences (A.R.S.), Head and Neck Surgery (N.V., A.I.), and Neurology (G.I.), David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California. Abstract Endolymphatic hydrops, the primary pathologic alteration in Menière disease, can be visualized by using delayed intravenous contrast-enhanced 3D-FLAIR MR imaging. It is not known whether MR imaging-demonstrable changes of hydrops fluctuate with disease activity or are fixed. We describe the results of baseline and posttreatment MR imaging studies in a group of subjects with Menière disease with hydrops who were treated with acetazolamide. Seven subjects with untreated Menière disease with MR imaging evidence of hydrops had repeat MR imaging during acetazolamide treatment. Symptoms and imaging findings were assessed at each time point. Five subjects showed symptom improvement, of whom 3 had improvement or resolution of hydrops. One subject had recurrent symptoms with recurrent hydrops after discontinuing therapy. Two had unchanged hydrops despite symptom improvement. Subjects with unchanged symptoms had unchanged hydrops. Hydrops reversal may be seen with acetazolamide treatment in Menière disease. MR imaging may provide an additional biomarker of disease. © 2016 American Society of Neuroradiology. FYI: Acetazolamide, usually sold under the trade name Diamox in some countries, is a carbonic anhydrase inhibitor that is used for the medical treatment of glaucoma, epileptic seizure, idiopathic intracranial hypertension, altitude sickness, cystinuria, periodic paralysis, central sleep apnea, and dural ectasia. Acetazolamide is a diuretic, and it is available as a generic drug in the United States. Diamox is now available as Diamox Sequels in the United States since the original product is no longer made or sold there.[1][2] It is on the World Health Organization's List of Essential Medicines, a list of the most important medications needed in a basic health system.[3]
In Sweden they are also testing a drug used for glaucoma patients on meniere's patients to see it's effectiveness. In March of next year the results should be in, I spoke to the doctor doing the research will let you guys know. I mention this because this drug that you posted also is used to treat glaucoma
Thanks prozeal. It should be interesting to hear those results. The study above was only done with 7 people, hopefully someone will do a larger one.
I tried Acetazolamide with no success last year , anyone else try it? We can have our own study here right now.
they didn't state the dosage, I wonder if that makes a difference, also the study says reversal of EH, but yet once some of the participants stopped the med EH came back. So it would not be a permanent solution if it did work.
I have been taking it for 3 years now. I started at 125 mg twice a day. After last Dr appt. I am now at 125 mg a day. Since being on it I have passed 4 ECOGs after failing one. I also take Valtrex and part of JOH and allergy shots. I am atypical just off balance in the beginning but hardly ever anymore.
I'm happy to hear you are doing well, but how do you know if its the Valtrex, allergy shots or diuretic that is suppressing your symptoms? Since being on the AV have you stopped the diuretic and see if there is any difference? or visa versa? stopped the AV etc etc?