Lysine, Vit C and Inositol

It takes about 2 hrs for food to clear from the stomach. Take lysine at least 20 min before eating, or 2 hrs after.

If taken with food, lysine gets mixed with all the other amino acids in food and the body uses it for normal synthesis of proteins. When taken alone, it resides in the blood for a longer period of time, allowing it to disrupt herpes virus replication.

But not only is the timing of consumption crucial, so is the amount of lysine taken. The best results against Meniere's symptoms have been with 1000mg taken t.i.d., which is a gram taken 3 times a day.

Information here: http://www.zoominternet.net/~kcshop/JOH.pdf

--John of Ohio

 

A single 3000 mg dose may be effective in suppressing an already suppressed herpes population (from the antiherpetic drug). But the evidence for both lysine and antiherpetics supports a keep-it-level dosing procedure. Apparently, the virus can resume replication in a few hours or longer when drug or lysine levels in the blood are low. Neither agent accumulates in inner ear tissues from single daily dosings. Instead, those agents need to be at consistent, high-enough concentrations in the blood to sufficiently retard replication.

Try to pop a gram of lysine immediately when you wake up (20 min before breakfast). Another in mid-afternoon (2 hrs after lunch), and a final dosing just when you go to bed.

--John of Ohio

 

Yes, lysine is a naturally-occuring amino acid, found in all protein-containing foods. The body is programmed to digest and metabolize it, to take it in and use it to synthesize new proteins. It doesn't hang around in the blood very long before the body productively uses it.

But drugs, such as the antiherpetics, are removed much more slowly from the blood, by a cascade of comlicated chemical processes in the liver. The body has no natural use or affinity for these (or most other) drugs. They are chemically regarded by the kidneys and liver as poisons, and are eliminated. But that can take many hours. The whole topic is "pharmacokinetics," the rate at which substances in the blood are destroyed or eliminated, usually measured in "half-life." Detailed technical data on all drugs will indicate the measured drug half-life, which is often in the range of 8 to 12 hrs or so. Twelve hours after injestion, half of the drug will be gone. Twenty-four hrs later, 3/4s will be gone. Lysine, because it is a common (and essential) nutrient is quickly taken up for protein synthesis. It's serum half-life is just a few hours or so. Hence, the utility and neccessity of three times a day dosings.

In fact, some pharmacists would agree to slicing the antiherpetic tablets in half, and taking them in two daily dosings, which would give a more consistent serum level of the drug. But everyone knows (all of us, for sure) taking lots of pills lots of times a day is just a pain and dosings are easily neglected or missed. I'm certain that a fraction of those who didn't get any relief from my regimen were not consistently, persistently attentive to three-times-a-day dosings of the lysine (and being careful not to mix the lysine with food). All rather difficult. But the biochemistry of the body and lysine demand such precise attentiveness.

Same is true, too, for the antihepetics. Those, too, need to be taken exactly as prescribed. Skip a day, and the herpes viruses can then start replicating again, setting off the consequent cascade of imflamation that produces all of Meniere's symptoms. Adherring to dosing instructions is called "compliance." Physicians know that many therapies they prescribe fail because of patient non-compliance. The stuff wasn't taken when, how, and as frequently or as long as prescribed. Drives doctors nuts. Just lots of therapies require strict compliance. Lazy or haphazard dosings fail.

--John of Ohio