http://www.neurologyreviews-digital.com/neurologyreviews/nr_scns_march_2016_supplement?pg=1#pg1 Phase II Trials Appear to Validate CGRP as a Promising Target in the Treatment of Migraine ============================= New players in the preventive treatment of migraine http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4641418/ Conclusions Migraine is a common, chronic neurovascular disorder of the brain with cranial autonomic findings. It is characterized by recurrent, severe attacks of headaches often associated with other symptoms and much disability, as well as personal, familial and societal impact. Currently, there only are a limited number of preventive treatments for migraine worldwide, and they often are ineffective and cause AEs leading to low retention rates. Better therapies are badly needed. CGRP-mAbs to the ligand and receptor display at least, if not greater, comparable efficacy to the currently available oral therapies, with better safety data and perhaps adherence in phase 2 trials. Neurostimulation also appears promising, despite the limited evidence. Both monoclonal antibodies and neurostimulation appear to offer effective, novel management for migraine prevention and acute care of chronic cluster headache. We look forward to further results of these above therapies.
I saw the word 'neurostimulation' while I was using a device called the Fisher Wallace Stimulator. It's marketed for depression, anxiety and insomnia. I just Googled and it's claimed the device is also good for reducing migraine. I've been using it for five days and it's supposed to take up to two weeks to start having effect but something is subtly beginning to help. I say something as I was recently diagnosed as being pre-diabetic (I'm not overweight but have a family history of type 2) and have given up sugar/carbs etc. My depression melted away overnight...who'd have thought sugar could affect your emotions so badly? The Fisher Wallace Stimulator is available through prescription in the US, but freely available elsewhere (I'm an Aussie). I ordered it and it was here within five days. Be awesome if it helped my vestibular migraine!