Expanding antigen-specific regulatory networks to treat autoimmunity. Clemente-Casares X1, Blanco J2,3, Ambalavanan P1, Yamanouchi J1, Singha S1, Fandos C2, Tsai S1, Wang J1, Garabatos N4, Izquierdo C4, Agrawal S5, Keough MB5, Yong VW5, James E6, Moore A7, Yang Y1,8, Stratmann T4, Serra P2, Santamaria P1,2. Author information Abstract Regulatory T cells hold promise as targets for therapeutic intervention in autoimmunity, but approaches capable of expanding antigen-specific regulatory T cells in vivo are currently not available. Here we show that systemic delivery of nanoparticles coated with autoimmune-disease-relevant peptides bound to major histocompatibility complex class II (pMHCII) molecules triggers the generation and expansion of antigen-specific regulatory CD4(+) T cell type 1 (TR1)-like cells in different mouse models, including mice humanized with lymphocytes from patients, leading to resolution of established autoimmune phenomena. Ten pMHCII-based nanomedicines show similar biological effects, regardless of genetic background, prevalence of the cognate T-cell population or MHC restriction. These nanomedicines promote the differentiation of disease-primed autoreactive T cells into TR1-like cells, which in turn suppress autoantigen-loaded antigen-presenting cells and drive the differentiation of cognate B cells into disease-suppressing regulatory B cells, without compromising systemic immunity. pMHCII-based nanomedicines thus represent a new class of drugs, potentially useful for treating a broad spectrum of autoimmune conditions in a disease-specific manner.
Vicki - after all your hard work and effort in posting this I feel it warrants a comment of some description, so here's mine. I haven't a bloody clue what it's on about ;D
LOL basically they are saying for autoimmune disease they are finding that specific antigens will target specific diseases which would fix the immune system. and they treat it using nanoparticles that have the specific antigen for each particular disease. They are also using nanomedicine with food allergies. Using nanoparticles of the protein of a person allergen to get their immune system to recognize it as friend not foe.
Keefer You are not the only one who did not understand what Vicki posted. ( Vicki thank you for the explanation !) I am more than positive that it was brain fog ha ha
LOL Keefer and Marta I have to read technical stuff a few times for it to sink in. Mine is not brain fog its just hard stuff to understand LOL But its very exciting news having a new class of medicines that can target autoimmune disease, which MAV and MM most likely are along with a host of other diseases.