Nootropics

I was reading about nootropics and I thought they could help with coping everyday MD symptoms like fatigue, lack of concentration, decreased mental performance and even to increase the mood.

I dug deeper into research and found that some of them are even in use for the treatment of acute hearing loss and tinnitus.

Here is the cognitive enhancers list:

• Piracetam: reduces cognitive decline with age;

Nootropics such as piracetam are supposed to increase the vigilance and intellectual abilities of demented individuals due to an "improvement in the microcirculation and metabolic processes in the brain", without any mechanism of action having yet been clarified. These medications have also applied for the treatment of acute hearing loss and tinnitus.
Source:
Therapy of hearing disorders - conservative procedures

• Aniracetam: memory increase, it is also a mild antidepressant;

• Phenylpiracetam: is banned in professional athletics because it increases physical performance. It is arguably the most stimulating of the racetams;

• Modafinil: Performance enhancing. It has been shown to increase resilience and improve your mood. In healthy adults, it improves fatigue levels, motivation, reaction time, and vigilance. It even improves brain function in sleep-deprived doctors. It has become more and more well known among entrepreneurs, executives, and even college students looking for an edge;

• Bacopa Monnieri – attention, mood, stress, memory;

• Deprenyl: Works on dopamine receptors for cognitive enhancement;

• CoQ10: Helps your mitochondria produce energy;

• Curcumin: Improves memory and attention while acting as an antioxidant.

I hope this info will help for some.

 

You need to take at least 750 mg of Bacopa Monnieri daily and with a fat source to increase its absorption and at least for one month to start to notice some effect.
But Bacopa Monnieri is a natural compound and I think you won't notice a dramatic effect from it.

Synthetic compounds like Piracetam, Aniracetam, Phenylpiracetam, and especially Modafinil are a different story.
Modafinil even got a name "limitless" from the famous movie Limitless
Limitless (2011) - IMDb

Modafinil is very popular in the silicon valley among the young entrepreneurs. With this "limitless" pill you can work very productive and long hours without the need of a sleep.
But Modafinil in some countries is not even registered as a drug and belongs to the group of psychotropic substances whose use or disposal is subject to criminal liability.

For me, the most appealing is Piracetam. It is registered in most countries like a drug and you can use it legally like a drug with the prescription. More than that, in the medicine it is recommended for the treatment of acute hearing loss and tinnitus. So I think, getting a prescription for this drug from a neurologist won't be difficult if you have an MD diagnosis and if you suffer from fatigue, lack of concentration and decreased mental performance.

 

The effectiveness of piracetam in vertigo

Piracetam has been shown to be effective in vertigo of both central and peripheral origin.

The effectiveness of piracetam in vertigo - PubMed

 

Piracetam infusions in acute tinnitus and sudden deafness

Improvement in hearing was 15 dB (piracetam) versus 18.5 dB (naftidrofuryl). The improvement in tinnitus amounted 27 dB (piracetam) and 19.9 dB (naftidrofuryl).

Piracetam, which improves rheology and has a positive effect on metabolism, would appear of particular interest for the treatment of acute tinnitus.

[Piracetam infusions in acute tinnitus and sudden deafness] - PubMed

 

Today I am starting the experiment with the piracetam. The starting dose is 1200 mg twice daily. Later on, I am planning to increase the dose to 1200 mg three times daily and 2400 mg two times daily.

The experiment goal is to check whether it will affect my tinnitus, hearing and productivity in a good way.

The study results above about tinnitus and hearing improvements look very promising.

Besides, I didn't find any info about piracetam in this forum, looks like I will be the first here with such an experiment.

 

I checked Piracetam indications on drug information booklet and found this info:

For the treatment of dizziness and imbalance due to disorders of the inner ear (excluding dizziness due to circulatory disorders and mental causes).

Very interesting, why don't ENT doctors offer this drug for inner ear balance problems, only Betaserc or Cinarizine?

There is also a study showing that Piracetam is effective in vertigo of both central and peripheral origin. That is what we need in Meniere's disease.

 

Turmeric supplements cause brain stem cells to grow both in live animals and in lab cultures.

We propose that ar-turmerone constitutes a promising future drug candidate to support regeneration in neurologic disorders.

Joerg Hucklenbroich et al., “Aromatic-Turmerone Induces Neural Stem Cell Proliferation in vitro and in vivo,” Stem Cell Research & Therapy 5, no. 4 (September 26, 2014): 100
Aromatic-turmerone induces neural stem cell proliferation in vitro and in vivo | Stem Cell Research & Therapy | Full Text

 

Hi Donamo!
Piracetam is a drug, not a supplement, to get it, I needed to convince my doctor to give me a prescription.

Piracetam, phenylpiracetam, and aniracetam drugs, which have been around since the 1960s, raise oxygen in the brain and improve mitochondrial dysfunction after oxidative stress. The first positive studies came out in 1971, yet these pharmaceuticals were almost entirely absent from the United States. They weren’t banned in the United States, but they weren’t embraced, either, putting them in a “gray zone” where they still reside today.

 

Here is another interesting study about piracetam:

Oral Piracetam vs Betahistine in Outpatient Management of Peripheral Vertigo; a Randomized Clinical Trial

Conclusion: Oral piracetam is a potentially proper treatment for management of peripheral vertigo and there are few adverse effects associated with it.

Oral Piracetam vs Betahistine in Outpatient Management of Peripheral Vertigo; a Randomized Clinical Trial - PubMed