Hello all - I research auditory disorders. I am interested in a compound called N,N-diisopropyltryptamine (DiPT), that seems to transiently recapitulate the symptoms of Meniere's - most notably bilateral diplacusis, aural fullness, and in some cases, tinnitus. What is very notable is that the downward shift in pitch perception is its most prominent feature. They call this state 'diptogenia'. It also binds to serotonin receptors that give it strong emotional effects that resemble psychedelic compounds. It has seen minor usage as a recreational drug. A paper was recently written about it here: https://academic.oup.com/braincomms/article/8/2/fcag093/8644266 There is also another chemically-related compound, 5-MeO-DET, that induces vertigo, nausea, and tinnitus (see 'Qualitative Comments' section here: Erowid Online Books : "TIHKAL" - #36. 5-MEO-DET). All of these compounds are also chemically similar to betahistine. Why this is notable is that these compounds could be used to model Meniere's in animal models, enabling scientists to make new insights into the aetiology of Meniere's disease. I would be keen to know your thoughts on this, and how similarly your experience of Meniere's disease is to 'diptogenia'. Best wishes to you all, and thank you in advance for your time.
Hi - I am a Meniere's sufferer and patient advocate (I run two large FB support groups and also write a very active Substack about Meniere's and the research into it). I am also a musician and it is the diplacusis and pitch perception issues that have been the biggest problem. Hearing my own or other instruments in some ranges out by several semitones at times, typically lower than they should be. I'd love to talk to you about your research as I feel the whole area of pitch distortion is massive in Meniere's and rarely discussed.
I would second this. The downshifting diplacusis is a major problem that deserves much more research and discussion!