Has anyone tried to get Ebselen (SPI-1005) online?

A lot of us heard about the Sound Pharmaceuticals SPI-1005 and some of us were participating in this trial and reporting that SPI-1005 works.

In this trial Sound Pharmaceuticals are using anti-inflammatory and anti-neoplastic agent Ebselen, to be exact 400 mg daily doses of Ebselen.

So, has anyone tried to get Ebselen online, especially those who were participating in SPI-1005 trial and knows it works for them?

 

I am doing much better than in the first 3 months of my disease. Now I hit 7 months of my MD disease mark. There are no instability attacks anymore, strong hearing fluctuations and strong hearing distortions, but what worries me the most now, there are no 100% symptoms free days anymore as was in the beginning and also I am experiencing new symptoms which are even difficult to describe.

So feeling everyday these symptoms and the thought that it is gonna last the rest of my life is driving me crazy..life is not easy and living with this shit when I can't concentrate on my job and other important things is even more difficult..

Besides, after 1.5 months I canceled taking Acyclovir. Don't feel any difference in my MD symptoms and I think I started to get side effects like skin rash and others.
I am still taking NAC 3 gr daily for almost 2 months, but don't know whether it is affecting my MD.

 

Decided to check what prices are now for the Ebselen (SPI-1005) and what treatment cost for MD we could expect if Sound Pharmaceuticals study for Meniere's disease will succeed.

So I dug into Sound Pharmaceuticals Meniere's disease Phase 2 study:

SPI-1005 for the Treatment of Patients With Meniere's Disease
This study will evaluate the safety, efficacy, and Pharmacokinetics (PK) of two dose levels of SPI-1005 administered for 28 days compared to placebo in patients with Meniere's disease.

Tree groups:

1. Placebo
2. 200mg of Ebselen (SPI-1005) twice daily;
3. 400mg of Ebselen (SPI-1005) twice daily.

Source:
SPI-1005 for the Treatment of Patients With Meniere's Disease - Full Text View - ClinicalTrials.gov

The lowest price for Ebselen (SPI-1005) I found was 5950 USD for 20 grams if we buy in bulk.
Source:
Ebselen | SPI-1005 | CAS#60940-34-3 | Organoselenium | Anti-Inflammatory | Cytoprotective Activity | MedKoo Biosciences

So, for the (200mg of Ebselen twice daily) group, for 28 days you will need 11,2 grams of Ebselen and it will cost approximately 3332 USD.

For another (400mg of Ebselen twice daily) group, for 28 days you will need 22,4 grams of Ebselen and it will cost approximately 6664 USD.

According to this forum member Mac, Ebselen works only if you take it. When you stop taking it, after some time, MD symptoms are coming back.

It’s no wonder we haven't heard of self-testing with Ebselen.

So now I am thinking whether it will be a real treatment at all when the prices are so high (3000-6000 USD monthly) or maybe all of this will be covered by medical insurance?

As I know now, the most expensive treatment for MD is Orthokine / Regenokine therapy. One procedure could cost you about 7000 - 10 000 USD and it's not covered by medical insurance. Besides, after half a year you need to repeat it for better effect and there is no guarantee you will get rid of MD symptoms once and for all. There are reports that despite such an expensive treatment, MD symptoms are returning after a year or two.

 

I don't believe there would be large quantities, we are only about 0,2% of the population. Also not all countries will include this medicine in their treatment plans, like happened with the Serc. Also due to the high price of the drug, medical insurance most likely won't cover the treatment plan how it is with the Orthokine / Regenokine therapy.

 

Ebselen (also called PZ 51, DR3305, and SPI-1005), is a synthetic organoselenium drug molecule.
Source:
Ebselen - Wikipedia

 

While we are waiting for Ebselen to be approved for the Meniere's disease and hoping that treatment will be available for everyone in terms of price and will be effective, my proposal is to find alternatives with which we can mimic Ebselen’s properties.

Ebselen (also called SPI-1005), is a synthetic organoselenium drug molecule with anti-inflammatory, anti-oxidant and cytoprotective activity.

So for the anti-inflammatory I would suggest to try Serrapeptase or liquid curcumin.
About Serrapeptase you can find more here:
Serrapeptase
TMJ

About curcumin you can find more here:
Pterostilbene and resveratrol. Has anyone tried them?
Pterostilbene and resveratrol. Has anyone tried them?

For the anti-oxidant I would suggest to try NAC. NAC, like Ebselen, mimics and induces glutathione peroxidase and both molecules work in similar ways.
About NAC you can find more here:
SPI-1005 Enters Phase 3 Trials, on fast track with FDA - Sept. 2019

For the cytoprotective activity (is a process by which chemical compounds provide protection to cells against harmful agents) I would suggest to eat more broccoli (Sulforaphane), brussel sprouts and Thai ginger (pinostrobin).
Sulforaphane found in broccoli is considered an indirect antioxidant, this compound is able to induce many cytoprotective proteins. Also it is possible to take broccoli extract as supplement which is rich in Sulforaphane.
Source:
Protective effect of sulforaphane against oxidative stress: recent advances - PubMed

Also cytoprotection properties have resveratrol and the same curcumin and they can be taken as supplements.
Source:
Cytoprotective Effects of Natural Compounds against Oxidative Stress

More about resveratrol benefits you can find here:
Pterostilbene and resveratrol. Has anyone tried them?

 

Well in China you can buy the same Ebselen (also called SPI-1005) for a much cheaper price. I checked several vendors and found quite good price

1 kg of Ebselen - 5560 USD

Ebselen suppliers & manufacturers in China

So, for the 200mg of Ebselen twice daily and for 28 days you will need 11,2 grams of Ebselen and it will cost approximately 63 USD.

For 400mg of Ebselen twice daily and for 28 days you will need 22,4 grams of Ebselen and it will cost approximately 125 USD.

Monthly treatment cost with the Ebselen now is similar to AVs.

There is still no FDA approval for treating MD with Ebselen nor with AVs, but a lot of us tried AVs and were having success, so why not to try Ebselen?

 

Should I take NAC or Glutathione to increase my body's antioxidant levels?

Well it could be neither one of these.

Glutathione is a powerful antioxidant, but has poor absorption and by taking glutathione supplements you most likely won't increase your glutathione levels in your body.

Another way to increase glutathione levels is by doing this indirectly by taking NAC supplements.



NAC is a precursor to cysteine which is a vital precursor to glutathione, but your body so long as there's not a massive oxidant stress can produce all of the precursors that it needs.

So is there something we can do to increase glutathione levels in our body?

Well one study shows that we can do this by activating NRF2





What's really interesting is telling our body to create more glutathione and we can do this by switching on in our NRF2 and the best molecule that we have to do this is sulforaphane.
One study shows that we can increase glutathione levels 2.4 fold with sulforaphane molecule



But unfortunately sulforaphane is highly unstable and if you take sulforaphane supplements it will degrade by the time you take it in.

So to solve this problem the best way to eat broccoli sprouts. Broccoli sprouts have two molecules in it glucoraphanin and myrosinase and when these two are combined in our digestive tract it creates sulforaphane.

glucoraphanin + myrosinase = sulforaphane

If you don't like broccoli sprouts, you can take broccoli supplements which have glucoraphanin and myrosinase in it.

So what do you think, are you going to take NAC supplements or broccoli sprouts instead?

 

So there are lots of broccoli extract supplements to buy online. The majority of them are only offering sulforaphane in it.

So according to the information above sulforaphane is unstable and it's better to choose those broccoli supplements which have glucoraphanin a.k.a. sulforaphane glucosinolate and preserved myrosinase enzyme in the broccoli that metabolizes sulforaphane glucosinolate (a.k.a. glucoraphanin) in the small intestine into sulforaphane.

glucoraphanin (a.k.a. sulforaphane glucosinolate) + myrosinase = sulforaphane

 

I noticed that the most convenient way to find those broccoli supplements in the online shops which have both (glucoraphanin + myrosinase) is to search only for myrosinase.

 

Some broccoli extract supplement producers are even mentioning the importance of NRF2 protein activation.