I was diagnosed with Meniere's disease in late August this year. The ENT put me on Spironolactone 25 mg once a day and a low NA diet. By late September, I had also been through four rounds of Predisone decreasing dose packs (horrible sleep disturbance from that.) October 4th I went to the ER because I had been so nauseated for 4 or 5 days that I couldn't eat, couldn't take any pills and just felt terrible. I was beginning to experience retching, but no vomiting because I hadn't eaten anything. I was shocked when the ER doctor said he was admitting me for a dangerously low sodium level (121). I was in the hospital for two nights on a very slow saline IV drip and liquid diet. My blood NA has always run at the low end of normal, but I had been so healthy prior to the Meniere's diagnosis, that I never even thought about low NA as a cause of my nausea. I thought maybe I had flu or something. (I'm 78 years old) I am no longer taking the diuretic and am not following a strict low NA diet either. I have gradually begun to feel better, and fortunately (knock wood), besides chronic tinnitus, I have regained most of the hearing in my left ear and haven't had anymore attacks of vertigo. Currently, I am taking L-Lysine and Lemon Bioflavonoids daily. I have seen an otology/neuro specialist and will follow up with him. (I will get an MRI in a couple of days and another hearing test when I see him again.) He is open to treatments such as Betahistine and Acyclovir if they might be helpful. At the moment I'm in a wait and watch phase. I wonder if others have experienced such serious side effects from the diuretics and low NA diet regimen. It was a total and unexpected shock to me.