This is a very long study. I just pasted the introduction and conclusion to read the entire study click on the abstract link Abstract http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3276397/ Common dietary components including vitamins A and D, omega-3 and probiotics are now widely accepted to be essential to protect against many diseases with an inflammatory nature. On the other hand, high-fat diets are documented to exert multiple deleterious effects, including fatty liver diseases. Here we discuss the effect of dietary components on regulatory T cell (Treg) homeostasis, a central element of the immune system to prevent chronic tissue inflammation. Accordingly, evidence on the impact of dietary components on diseases in which Tregs play an influential role will be discussed. We will review chronic tissue-specific autoimmune and inflammatory conditions such as inflammatory bowel disease, type 1 diabetes mellitus, multiple sclerosis, rheumatoid arthritis and allergies among chronic diseases where dietary factors could have a direct influence via modulation of Tregs homeostasis and functions. INTRODUCTION Regulatory T cells (Tregs) are a heterogeneous T-cell subpopulation that regulates the immune system in various ways. Given the significance that deregulation of the immune system plays in the development and progression of chronic inflammatory processes, including inflammatory bowel disease (IBD), type 1 diabetes mellitus (T1D), asthma, arthritis and multiple sclerosis (MS), the factors influencing and influenced by Tregs may offer insight in the mechanisms underlying the pathological course of these diseases as well as provide clues to improving their management. The mechanisms involved in the generation and maintenance of Tregs on the cellular level and in the host environment are just starting to be understood. It is even less clear how the environment-host interaction affects the immune balance and the status of Tregs. Nonetheless, a variety of model systems are available to interrogate the characteristics and function of Tregs in health and disease. Although, few studies directly look at the effect of common dietary components on Treg homeostasis, despite the important role shown for the influence of diet on inflammation and immune regulation. Accordingly, evidence on the impact of dietary components on diseases in which Tregs play an influential role may provide insight into the role of these dietary components on Tregs themselves. This report reviews some of the evidence showing how dietary components influence Tregs. Although dietary components have been reported to influence disease outcome via regulating other cells, such as helper T cells (Th1, Th2 and Th17), important in health and the pathogenesis of immune-related diseases, in this review, we restrict our focus to Tregs. Recently published results on the influence of dietary components on Tregs, including probiotics and vitamins, are discussed. In addition, related studies on the pathways involved in the modulation of Tregs by dietary components are also examined. In addition to the role of single components such as vitamins and the consequences of probiotics, gluten and fatty acids are also discussed. CONCLUSION CD4+CD25+FoxP3+ Tregs play a central role in maintaining peripheral immune tolerance. As such, it is not surprising that proper functioning of Tregs is important in gut-associated immunity. Even more understandable is why the critical gut-associated immune cell population, Tregs, adapts itself to the influence of recurrent ingested dietary components such as VitA and VitD, gluten and fatty acids. Additionally, as functional food containing probiotics become more widely available and popular, understanding the mode of action of these dietary factors on regulation of Treg homeostasis could prove valuable to control many chronic inflammatory conditions directly affecting the gut (IBD, Crohn’s disease) or indirectly influencing other chronic tissue inflammatory conditions (T1D, MS and RA) regulated by Tregs.
on another site I read this: http://selfhacked.com/2014/11/11/treg/ Tregs: The Missing Link To Cure Autoimmune and Inflammatory Disorders You can test your Treg Cell numbers by taking a blood test. This doesn’t check for some important aspects of Treg cells to my knowledge (Foxp3 nor ‘high’ CD25). However, since these cells are mostly are good against autoimmunity, checking the absolute number of cells should have some value. (R) Checking TGFb1 and IL-10 (checked in the Th1/Th2/Th17 dominance test) should give a clearer picture as to what your level of Tregs in like. This is because TGFb1 increases Tregs and IL-10 is given off by Tregs. I’d recommend all three tests to get a decent picture.