http://www.ncbi.nlm.nih.gov/pubmed/25510210 Am J Otolaryngol. 2015 Mar-Apr;36(2):205-9. doi: 10.1016/j.amjoto.2014.10.032. Epub 2014 Oct 30. Intratympanic dexamethasone versus high dosage of betahistine in the treatment of intractable unilateral Meniere disease. Albu S1, Chirtes F2, Trombitas V2, Nagy A3, Marceanu L4, Babighian G5, Trabalzini F5. Author information 1Second Department of Otolaryngology, Iuliu Hatieganu University of Medicine and Pharmacy Cluj-Napoca, Cluj-Napoca, Romania; Ro-Neuro Clinic Cluj-Napoca, Romania. Electronic address: [email protected]. 2Second Department of Otolaryngology, Iuliu Hatieganu University of Medicine and Pharmacy Cluj-Napoca, Cluj-Napoca, Romania. 3Ro-Neuro Clinic Cluj-Napoca, Romania. 4University of Medicine and Pharmacy Brasov, Romania. 5Operative Unit of Otolaryngology and Otosurgery, Padua University, Padua, Italy. Abstract PURPOSE: The objective of our randomized, double-blind study was to compare the effectiveness of intratympanic (IT) dexamethasone versus high-dosage of betahistine in the treatment of patients with intractable unilateral Meniere disease (MD). MATERIALS AND METHODS: Sixty six patients with definite unilateral MD were randomly divided in two groups: Group A received a combination of IT dexamethasone (DX) and identical-appearing placebo pills while Group B received a combination of high-dosage betahistine and IT saline. Intratympanic injections were repeated for three times with an interlude of 3days. High-dosage of betahistine entailed 144mg/day. Mean outcome measures consisted of vertigo control, pure tone average (PTA), speech discrimination score, Functional Level Score, Dizziness Handicap Inventory and Tinnitus Handicap Inventory. RESULTS: Fifty nine patients completed the study and were available at 12months for analysis. In Group A complete vertigo control (class A) was attained in 14 patients (46.6%) and substantial control (class B) in 7 patients (20%). In Group B, 12 patients (41%) achieved complete vertigo control (class A), 5 patients (17%) substantial control (class B). There is no statistical difference in vertigo control between the two treatment groups. In Group A hearing was unchanged in 14 patients and improved in 4 patients, while in Group B hearing was unchanged in 16 patients and improved in 2 patients. CONCLUSIONS: Our preliminary results demonstrate that high-dosage of betahistine achieved similar outcomes as IT dexamethasone in the control of vertigo and hearing preservation.
144 mg a day that is high. is that the normal high dosage people are being prescribed and for what time period are they staying on this dosage. Do you start tapering off at some point?
High-dosage betahistine dihydrochloride between 288 and 480 mg/day in patients with severe Menière's disease: a case series. Department of Neurology, Klinikum Grosshadern, Marchioninistrasse 15, 81377 Munich, Germany. The objective of this study was to evaluate the clinical benefit and the side effects of high dosages of betahistine dihydrochloride (288-480 mg/day) in patients with severe Menière's disease (MD). In this case series 11 patients with MD who had not responded sufficiently to a dosage of 144 mg/day of betahistine dihydrochloride were treated on an individual basis with daily dosages between 288 and 480 mg of betahistine dihydrochloride. The number of attacks per month and the side effects were monitored. Non-parametric tests were used for statistical analysis. As a result, the frequency and the severity of vertigo were significantly reduced in all patients. The side effects were mild, self-limiting, and did not require any change in the treatment strategy. Despite the considerable limitations of an observational study--in particular in MD--high dosages of betahistine dihydrochloride between 288 and 480 mg/day seem to be effective in patients who do not sufficiently respond to lower dosages. Moreover, such dosages are well tolerated.
thanks, getting a doctor to prescribe this dosage seems it would be difficult. derebery only prescribed 36mg a day.
You could download, print and present this PDF file to your doctor ... http://www.mediafire.com/view/lpb0v991ew69v66/High-dosage_betahistine.pdf You could also show him these pic's of a SERC prescribed container ... http://www.mediafire.com/view/xz58ybm3xz88a51/serc02.jpg http://www.mediafire.com/view/3eq6hq8dkm3pb5t/serc01.jpg Most North American doctors are oblivious to the benefits of high-dosage SERC. I had to educate my GP, my ENT specialist and even the pharmacist. If you want it, you have to go and get it. Good luck, Loo-Hoo.