Would be great if they can find a biomarker for Meniere's http://www.ncbi.nlm.nih.gov/pubmed/25330336 Autoimmunity as a Candidate for the Etiopathogenesis of Meniere's Disease: Detection of Autoimmune Reactions and Diagnostic Biomarker Candidate. Kim SH1, Kim JY2, Lee HJ3, Gi M2, Kim BG3, Choi JY4. Author information Abstract Meniere's disease is an inner ear disorder that can manifest as fluctuating vertigo, sensorineural hearing loss, tinnitus, and aural fullness. However, the pathologic mechanism of Meniere's disease is still unclear. In this study, we evaluated autoimmunity as a potential cause of Meniere's disease. In addition we tried to find useful biomarker candidates for diagnosis. We investigated the protein composition of human inner ear fluid using liquid column mass spectrometry, the autoimmune reaction between circulating autoantibodies in patient serum and multiple antigens using the Protoarray system, the immune reaction between patient serum and mouse inner ear tissues using western blot analysis. Nine proteins, including immunoglobulin and its variants and interferon regulatory factor 7, were found only in the inner ear fluid of patients with Meniere's disease. Enhanced immune reactions with 18 candidate antigens were detected in patients with Meniere's disease in Protoarray analysis; levels of 8 of these antigens were more than 10-fold higher in patients than in controls. Antigen-antibody reactions between mouse inner ear proteins with molecular weights of 23-48 kDa and 63-75 kDa and patient sera were detected in 8 patients. These findings suggest that autoimmunity could be one of the pathologic mechanisms behind Meniere's disease. Multiple autoantibodies and antigens may be involved in the autoimmune reaction. Specific antigens that caused immune reactions with patient's serum in Protoarray analysis can be candidates for the diagnostic biomarkers of Meniere's disease. Complete text here http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4201580/
Yeah, but where would that get you? I am told mine is most likely an autoimmune reaction to the release of sequestered proteins when the other ear was operated on. But be that as it may, i had great success with antivirals and allergy treatment. I have a feeling the autoimmune may be the start of it but not the whole answer and not necessarily the easiest place to start with remedies.
it would be a diagnostic tool since we don't really have one atm except process of elimination and history
Yes, but i doubt it would be definitive. I went ten years with the autoimmune factor and only when the others jumped on top did i 'get' menieres/cochlear hydrops symptomatically.
The abstract says they found specific proteins found in the inner ear fluid of Meniere's patients, we shall see if this pans out to anything, I am just happy researchers are still investigating.
Right but those proteins are probably also in the ears of some people who do not have menieres or have menieres yet. I equate it to the autopsy studies of hydrops. Much of the time hydrops equated to clinical menieres but there were cases of hydrops where there were no clinical symptoms and vice versa. It will be helpful but not definitive i would think.
they said it was 10 times greater in Meniere's patients. It's difficult to diagnose someone that doesn't have a disease yet. Once symptoms appear then a diagnosis is more easily made. Nothing with diagnosing or treating MM is definite, that's the problem