Pterostilbene and resveratrol. Has anyone tried them?

Yes, I use resveratrol since I saw this:

My experience with fasting only on water

To be exact, these compounds are Stilbenes.

Stilbenes are a class of polyphenolic compounds, naturally found in a wide variety of dietary sources such as grapes, berries, peanuts, red wine, and some medicinal plants. There are several well-known stilbenes including trans-resveratrol, pterostilbene, and 3′-hydroxypterostilbene. The core chemical structure of stilbene compounds is 1,2-diphenylethylene. Recently, stilbenes have attracted extensive attention and interest due to their wide range of health-beneficial effects such as anti-inflammation, -carcinogenic, -diabetes, and -dyslipidemia activities.

Resveratrol is the most extensively studied stilbene found in grape skin, berries, peanuts, and some medicinal plants. Hundreds of studies have shown that resveratrol plays a critical role in human health and diseases due to its diverse biological and pharmacological actions including antioxidation, -inflammation, -carcinogenic, and -diabetic potencies. However, one potential issue surrounding resveratrol is that resveratrol has a very low bioavailability that may lower its biological effectiveness.

It has been demonstrated that resveratrol possesses the potential of lifespan extension in various organism and animal models. Most reports suggested that the mechanism in regard to longevity promotion by resveratrol is related to calorie restriction.

Pterostilbene, natural dimethylated analogue of resveratrol, is a stilbenoid phytochemical compound primarily found in blueberries, grapes, and a tree wood, Pterocarpus marsupium.

Recent reports indicate that pterostilbene possesses high potential in bioactivities than its analogue resveratrol. However, there were only few studies investigating the anti-aging effects of pterostilbene.

Pterostilbene also improved the cellular stress, inflammation, and Alzheimer’s disease pathology through upregulation of PPAR-α expression, showing higher modulator potential than resveratrol.

Methylated modification of resveratrol found in pterostilbene and 3′-hydroxypterostilbene appeared to have stronger biological properties.
However, the human studies of stilbenoid compounds are still lacking, future clinical research for these compounds in chronic diseases is necessary to investigate their physiological and pharmacological effects and safety.

Source:
Biological actions and molecular effects of resveratrol, pterostilbene, and 3′-hydroxypterostilbene - ScienceDirect

According to professor David Sinclair, if you are interested in taking resveratrol, you need to use Trans-resveratrol (98-99% purity). Most importantly it should be white, not brown (brown is no longer effective) and you need to take it with the fat (for example it could be yogurt) for better absorption.

 

In a pharmacokinetic study, pterostilbene was shown to have 80% oral bioavailability in comparison to only 20% for resveratrol. Thus, the findings of these studies indicated that pterostilbene, dimethyl ether of resveratrol, showed much greater bioavailability than resveratrol.

 

I forgot to mention that I also use curcumin (turmeric). This compound has one of the strongest anti-inflammatory properties in nature and like stilbenes, it has a lot of other health benefits, one of these anticancer. Curcumin also strengthens intermittent fasting effect. In fact science just begun doing researches into these natural materials and we still don't know a lot about them.

Besides, one forum member mentioned that curcumin helps to alleviate ears pressure, I think this could be due to inner ear’s inflammation reduction.

If you deside to use curcumin, keep in mind that not all curcumin is equal. See how many curcuminoids your supplement has and also not all curcumin supplement forms are equal in case of absorption. Curcumin, like resveratrol, has absorption problems.

I also use vitamin D - is a must supplement in winter time.

 

The most important part is curcuminoids. Standart turmeric curcumin has not a lot of curcuminoids, so it's better to look for curcumin extract where specified exact % of curcuminoids. The more procentige of curminoinds, the stronger the effect of the supplement.

Also important to know, curcumin has poor absorbency. There are researches showing that if you take curcumin together with black pepper (piperine) you can increase curcumin absorbance thenfolds. So some supplement producers are selling curcumin together with piperine extract for better absorbency. But recently appeared on the market liquid curcumin and producers are claiming that they increased curcumin absorbance hundred folds compared to standard curcumin.

That forum member who mentioned curcumin helps to alleviate ears pressure wrote that when he tried liquid curcumin didn't want to return to standard curcumin anymore.

I personally haven't tried liquid curcumin yet. I started with the curcumin extract which one capsule has 450 mg curcuminoids + piperine extract. Later on I am going to try and liquid curcumin.

P.S.: don't know about the ginger.

 

Don't know which pterostilbene is better to choose, but I think the dose matters. The higher amount of pterostilbene in one capsule is, the more effect should be.

I myself am going to add pterostilbene in the future, but for now I am trying to add or take out one thing at a time.

 

There is more curcumin benefits:

A 2018 study out of UCLA confirms that a daily dose of curcumin—the active ingredient in turmeric—improves memory and mood in people with age-related memory loss. In the double-blind, placebo-controlled study, forty adults between the ages of fifty and ninety who complained of memory issues were assigned to one of two groups. Group one received a placebo, while group two received 90 milligrams of curcumin twice daily for eighteen months. All forty participants took standardized cognitive assessments at the study’s inception and then at six-month intervals. Thirty of the participants also underwent positron emission tomography (PET) scans to monitor brain amyloids before starting and then again after eighteen months. The results revealed that the participants who took curcumin experienced markedly improved memory and attention abilities. In fact, the people taking curcumin improved their memory scores by an average of 28 percent over eighteen months. This group also noted mood improvements, and their brain PET scans showed less amyloid buildup. To reap curcumin’s maximum longevity benefits, take it in supplement form. Pair it with bromelain (a digestive enzyme found in pineapple), or take it in an oil-based capsule to increase your body’s ability to absorb and utilize curcumin.

 

Here I want to mention and PYRROLOQUINOLINE QUINONE (PQQ).
This antioxidant is about a hundred times as powerful as vitamin C at protecting your cells from free radicals to keep them young. It also stimulates NGF, which helps you grow new neurons, and has been found to enhance the regeneration of peripheral nerves that connect the brain and spinal cord to the rest of the body.

Research on mice supports PQQ’s ability to kick mitochondria into high gear. Specifically, it can increase mitochondrial density to provide more energy, reduce inflammation, boost metabolism, combat oxidative stress, improve learning and memory ability, and protect the heart.

PQQ also activates PCG-1 alpha in the same way that exercise and nicotine do, which sparks mitochondrial biogenesis. This means that one supplement can enhance your existing mitochondria and help you grow new ones, all while acting as an incredibly powerful antioxidant. It’s pretty much the holy grail of longevity.

I wrapped PQQ molecules in a protective coating of oil called a liposome to help them absorb.

 

Found this info on vitamin D:

A recent study which came out last month by the 'Medical Hypothesis Journal' found that Vitamin D supplementation may help improve the symptoms of Ménière's.

This is because Vitamin D helps regulate the immune system, reduce inflammation and heal a leaky gut (the root cause of autoimmune conditions).

The benefit of Vitamin D in autoimmune conditions has been widely researched, but this is the first study specifically looking at the benefit of Vitamin D in Ménière's.

If you have never had your vitamin D levels checked I'd recommend taking 3000 IU per day. However people with Ménière's may need up to 4000 IU per day initially, but I'd only recommend taking this much if your vitamin D levels have been tested first. For a maintenance dose, I'd then recommend 2000 IU per day.

 

Vitamin D is very inexpensive and has such broad-ranging positive implications for optimal health that I consider it a must have supplement even for the average person. Not to mention Vitamin D deficiency is rampant.

Recommendations for the optimal amount for the average person is 1000iu - 4000iu daily. Amounts up to 10,000iu have not shown toxicity but this would not be recommended for a maintenance dose. I would agree with Mindosa on the 2000-3000iu daily supplementation range for anybody but especially we in the MD Club....

 

When taking Vitamin D3, make sure you also supplement with MK-7 Vitamin K2 to help your body absorb the D.

 

There is only one way to find out, to try it on yourself.

 

I thought you only needed to take K2 together with vitamin D and alongside with calcium for better calcium absorption, but not for the better vitamin D absorption?