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SERC (Betahistine Hydrochloride) and the Meniere's Patient

  1. solari

    solari MM.org Janitor Staff Member

    Admin Post
    (Copied over from our old MM.org archives)

    By George Martin

    Without going into too much detail for now, let me just say that some of us have suffered a lot with this problem and the typical remedies such as [endolymphatic] sac surgery, diet, various blood vessel dilators, diuretics, and Antivert just won't take care of the problem. I have been through all of the aforementioned treatments with very little success and was very discouraged.

    In July 1993 I had a major Meniere's Disease attack and I was convinced that I was having a heart attack. My wife called EMS [paramedics] and I was taken to the hospital where I stayed overnight to get my nausea under control. From that day until mid December I had daily attacks and some days several of them. (A previous shunt operation had no effect at all.) Nothing worked but at least with large doses of valium and transdermal neck patches (used to prevent seasickness) I was calm; actually I was like a zombie. As soon as the sedatives wore off, I was back in the swirl. I really began thinking that life was too short to tolerate such a style

    About this time I joined the National Meniere's support group of Tennessee. I read a letter to the editor in their "Steady" paper [monthly newsletter] reporting success using a medication called SERC (betahistine hydrochloride). I contacted the letter writer and received information on how to obtain the drug and have had tremendous success with its use. I have not had an attack since then and only know that I still have Meniere's when I try to cut back too much on my dosage. Unfortunately, SERC is not available in USA, but it is used in over 70 countries in the world as one of the primary treatments for Meniere's disease. Even though this seems to be a miracle drug for many of us, it fails to alleviate the problems for a few. Research shows that it is about 80% effective. I do wear 2 hearing aids, and have heavy tinnitus in the left ear. I have a 95db loss in the left ear and 65 db loss in the right one. But I have no dizziness, nausea, or full feeling in the head nor that questionable mental condition (called brain fog) that many of us have had. I feel great and hope that you do too.

    The local U.S. doctors can have little to do with SERC as this drug is not yet approved by the FDA. Doctors are very reluctant to say much about it or perhaps don't even know about it. Most of us who use it and have found success start out by taking 16 mg. 3 times per day until we are free of the vertigo, etc. You will generally not improve the tinnitus or hearing loss, but all the other symptoms will vanish (hopefully). I had to take this heavy dosage for nearly 5 weeks before I was entirely clear of the symptoms, but many find relief in a few days. Then I tapered back on the dosage. I now take 2 at breakfast, 1 at lunch, and 1 at dinner -- with food.

    I have a close friend here at the University of Texas who is a chemistry professor -- I took the pharmacy disclosure sheet to him to ask his advice. He said that the chemical makeup of SERC is as near as possible to our own body substance known as histamine and that it would take a ton of it to be harmful. The disclosure sheet does state that you shouldn't take antihistamine and SERC as they are opposite in reaction. Histamine is a natural blood vessel dilator while antihistamine tends to constrict blood vessels.

    To secure SERC [in the U.S.] today, one must either see a Canadian physician and be under his/her care to secure a prescription from a [Canadian] pharmacy, or go to Mexico and buy it as an over-the-counter drug. (EDIT: In the United States, a compounding pharmacy can make this for you with a prescription.)

    I have contacted the distributor of SERC, located in a suburb of Chicago. They have informed me that their company has been licensed to build a factory for production here in the [United] States. The company that makes it is ready to start phase 3 of testing for the USA and I have been told that this is testing on people (don't know this for a fact). Someday it will be available here in the States (if we can live that long).

    SERC (Betahistine Hydrochloride) Research
    Although you may have seen my patient report (above) concerning my successful use of the drug SERC, I felt that you may like to see SOME of the research that has verified that SERC eliminates most of the symptoms associated with Meniere's Disease.

    • In the Journal of the American Medical Association, April 11, 1966, vol. 196, no. 2, there is a detailed description of an evaluation of the drug betahistine hydrochloride (SERC) as used in the treatment of Meniere's Syndrome. The study is titled "Double-Blind Evaluation of a New Treatment for Meniere's Syndrome," by Joseph C. Elia, M.D. The summary of the article states the following:
      • "In a double-blind cross-over evaluation of betahistine hydrochloride for the symptomatic treatment of Meniere's Syndrome, the drug controlled the symptoms of vertigo, nausea and /or vomiting, tinnitus, and headache. Surgical intervention for the relief of vertigo associated with Meniere's syndrome no longer appears to be warranted."
    • An abstract titled "The Therapy of Tinnitus Tesulting from Blast Injury," written by Jakobs P. Martin (Germany), compares betahistine, pentoxifyllin and xantinol-nicotinate in the treatment of tinnitus. Using 172 patients, the results showed that those receiving betahistine produced significantly better therapeutic results in eliminating their tinnitus. The library unique identifier number for this abstract is 78150493 and the source -- HNO. 26(3):104-6, 1978 Mar.
    • An abstract titled "Betahistine treatment of Meniere's Disease" states the following results. Using betahistine hydrochloride treatment on 92 patients suffering from Meniere's Disease and Meniere's Syndrome, for a period of more than a year, the following was noted. 89% of the patients showed complete relief of vertigo-attack symptoms, 12% showed a distinct improvement in their hearing as reflected in their audiograms, 12% showed a further loss of hearing. Vertigo seemed to be the symptom most responsive to the treatment and tinnitus the most resistant. Minimal side effects were observed in 18% of patients. The library unique identifier number is 79071973 and the source -- Laryngologie, Rhinologie, Otologie. 57(11):997-1007, 1978 Nov.
    • An abstract titled, "Treatment of Acute Vestibular Vertigo" by Aantaa E. from Turku University Central Hospital in Finland states the following. When administering betahistine (SERC) to 613 patients at a dose of 8 mg. three times per day, 80% of the patients showed positive results. Betahistine is the current most effective drug in maintenance therapy of Meniere's disease, although it does not resolve all of the problem of the disorder. Betahistine also has minimal side-effects and it has not been shown to slow down habituation. The library unique identifier number for this abstract is 91268042 and the source -- Acta Oto-Laryngologica-Supplement. 479:44-7, 1991.
    • An abstract titled "Histamine in the Treatment of Vertigo" by Fischer AJ. of the Netherlands states this -- The vasodilating properties of histamine were the basis for histamine treatment of episodic vertigo and other inner ear dysfunctions. This led to the development of betahistine: an orally active histamine analogue; its general pharmacology resembles that of histamine. Animal pharmacology experiments proved that betahistine increases cerebral blood flow and probably also affects vestibular neurons. From clinical studies, it appears that betahistine is an effective agent for the symptomatic treatment of Meniere's Syndrome as well as patients suffering paroxysmal vertigo. The library unique identifier number for this abstract is 91298039 and the source -- Acta Oto-Laryngologica-Supplement. 479:24-8, 1991.
    SERC (Betahistine Hydrochloride) Package Insert
    Here is a copy of the disclosure sheet for SERC that I received from a Canadian source. The tablets in Canada are distributed by Sanofi Winthrop, Markham, Ontario, L3R 6H3, for Unimed, Inc.

    SERC (Betahistine hydrochloride)


    SERC is the proprietary name for a histamine-like drug generically designated as betahistine hydrochloride. The chemical name is 2 (2' meihylaminoethyl) pyridine dihydrochloride. There is some similarity in structure between betahistine and histamine.


    Betahistine was found to have a histamine-like action in animals. Since parenteral histamine has been used in the treatment of Meniere's disease, studies were conducted to test the action of betahistine in this condition. Unlike some other anti-vertigo drugs, testing with nystagmus induced by caloric and rotational stimulation has demonstrated that betahistine does not decrease the vestibular response, as recorded by electronystagmography. In addition, the absorption, metabolism and action of betahistine when administered by the oral route are not known. However, clinical studies indicate that SERC may be useful in reducing the vertigo of Meniere's disease.


    SERC may be of value in reducing the episodes of vertigo in Meniere's disease.


    The extremely variable course of Meniere's disease makes it almost impossible to predict. Consequently, assessment of the results of treatment is fraught with difficulties since spontaneous remissions or a placebo effect cannot be excluded, short of conducting prolonged studies extending over a period of years. The implication is that some information must be accepted from controlled trials falling short of an entirely acceptable design. In addition , most trials with betahistine have included a choice of patients with frequent episodes of vertigo that may not be representative of a cross section of patients with Meniere's disease.

    No studies are available comparing betahistine with other antivertigo agents. SERC has not been demonstrated to have any effect on the evolution or progression of Meniere's disease and it appears not to eliminate the development of incapacitating vertigo and the subsequent need for surgery in some patients.

    No claim is made for the effectiveness of SERC in the symptomatic treatment of any form of vertigo other than that associated with Meniere's disease. It also has not been established that betahistine has any effect on other manifestations of Meniere's disease.

    Meniere's disease, or idiopathic labyrinthine hydrops, is characterized clinically by recurrent episodes of vertigo accompanied by, usually unilateral, tinnitus and hearing loss. Nausea and vomiting may also occur. The vertigo lasts from a few minutes to several hours. Other forms of aural vertigo may be distinguished only because they tend to last longer. As a rule, between dizzy spells there are no other complaints save for varying levels of hearing and tinnitus. The prognosis in individual patients with Meniere's is difficult to predict. Some patients have mild or major dizzy spells in frequent clusters, possibly once or twice weekly, for a period of several weeks or months, then have remission of episodes which may last for months or years. Others may have vertiginous attacks only once or twice yearly. Virtually none have daily spells, and continuous vertigo in the sense of dizziness without remission for many days or weeks. In general, hearing is poorer and tinnitus loud when vertiginous attacks are frequent. Hearing may return to normal between attacks in early cases, but as time progresses, hearing slowly deteriorates, whether dizzy spells occur or not. In general, early Meniere's is featured by hearing levels which become worse with vertiginous attacks and improve even to normal between the attacks, while in late Meniere's hearing loss is less directly related to dizziness. The pathology of Meniere's disease consists of distention of the membranous labyrinth associated with accumulation due to overproduction or under absorption of endolymph.


    Several patients with a history of peptic ulcer have experienced an exacerbation of symptoms while using SERC. Although no causal relation has been established SERC is contraindicated in the presence of peptic ulcer and in patients with a history of this condition. SERC is also contraindicated in patients with pheochromocytoma.


    Although clinical intolerance to SERC by patients with bronchial asthma has not been demonstrated, caution should be exercised if the drug is used in these patients.

    SERC should not be used concurrently with antihistamine agents since no information is available with regard to the possible interaction of these drugs.

    The physician should be aware of the possibility of hitherto unreported adverse reactions to SERC.


    The safety of SERC in pregnancy has not been established. Therefore, its use in pregnancy or lactation, or in women of child bearing age requires that its potential benefits be weighed against the possible risks.


    Occasionaly patients have experienced gastric upset, nausea and headache.


    In the course of animal studies, the response to betahistine, following intravenous administration, and its action on a variety of isolated and intact tissues, resembled some of the responses to histamine. Intravenous administration of SERC produced a transient increase in blood flow through the labyrinthine artery in dogs, preceded by a fall in pulse pressure reflecting a systemic response. It is assumed that SERC could act by decreasing endolymphatic pressure as a result of increased vascularization. However, there is no experimental evidence of an increased perfusion of the stria vascularis or evidence that changes occur in the fluid physiology of the inner ear that would decrease distension of the membranous labyrinth. In addition, information on absorption, metabolism and excretion of betahistine hydrochloride has not yet been obtained.


    The lethal dose of betahistine hydrochloride for the albino rat is 3040 mg./kg. by the oral route. By the intravenous route the lethal dose for the rabbit is 5.1 mg./kg. The main signs of toxicity observed were: ataxia, salivation, inactivity, hyperpnea, tremors and cyanosis. The pathology revealed severe gastroenteritis.

    A two-litter reproductive study with rats revealed no adverse effects.

    Chronic toxicity studies in dogs given doses up to 25 mg./kg./day for eighteen months, revealed no significant abnormalities in the parameters measured.


    In the course of clinical trials with SERC several hundred patients with Meniere's disease were treated with this product. These studies have ranged from clinical experience with this drug during short or long periods of treatment to double-blind, placebo controlled trials. In view of the unpredictable natural history of Meniere's disease, no judgment of efficacy is possible in many studies with faulty designs or other serious defects.

    One study included approximately 60 patients with Meniere's disease, followed in a longitudinal fashion without a concurrent control group. All patients had evaluation of the vestibular function recorded by electronystagmography. The results of this study favor the efficacy of SERC in reducing vertigo. In addition, the vestibular function improved in the majority of patients that had a subjective response to the drug.

    Three double-blind placebo controlled studies suggest a possible therapeutic effect of the drug. No untoward clinical effects were noted.


    The usual adult dosage has been one to two tablets (4mg. each) administered orally three times a day. The dosage has ranged from two tablets per day to eight tablets per day. No more than eight tablets are recommended to be taken in any one day.

    SERC is not recommended for use in children. As with all drugs, SERC should be kept out of reach of children.


    Scored 4 mg. tablets in bottles of 100 tablets.
    Last edited: Nov 20, 2018
  2. LAC1300

    LAC1300 New Member

    Feb 14, 2020
    I am new to all this, just discovering this diagnosis in Oct 2019. I have been taking betahistine 8mg for about 2 months, but it is pretty expensive at the compounding pharmacy. I was looking for less expensive options. Does anyone know how to get it, short of a trip out of the country?
  3. California Sun

    California Sun Active Member

    May 23, 2019
    That's interesting...When I was first dx'd many years ago at House, I was prescribed something called "histamine". It was given as drops under the tongue and as an injection. There was a compounding pharmacy by the House Clinic that made it up for House's patients. I had wondered if it was similar to or related to Serc. Unfortunately, it didn't help me.
  4. MaryR

    MaryR New Member

    Jul 25, 2019
    Betahistine has significantly improved my vertigo. But I found that the usual prescribed dose did nothing for me, and I only had benefits from much, much higher doses. My neurotologist agreed with my request to take 48 mg 3 times a day, with the ability to increase the dosage to up to 10 times a day for emergencies. I never went that high, but on really bad days I found that taking 48mg 5 or 6 times a day kept the vertigo at bay.

    Right now I’m feeling great and have slowly tapered down to 48 mg 2x a day. Please note: Betahistine is just one of many, many supplements I take. I also do JOH, Valtrax, B5/B6, B12, CoQ, pycnogenol, triamterene (diuretic) and I just added in NAC based on the below post.
    This is the article that discusses the effectiveness of high doses of Betahistine :
    High-dosage betahistine dihydrochloride between 288 and 480 mg/day in patients with severe Menière's disease: a case series. - PubMed - NCBI
  5. Mel B

    Mel B New Member

    Feb 19, 2020
    So glad I found this article. I have had meniere's for almost 14 years and lived in NY when I was diagnosed. I was lucky to have a dr that was from Canada so could give me a prescription for this, which then could just go over to Canada to get. I don't remember it be very expensive at all. I haven't taken in almost 10 years as it didn't seem to help anymore, but 14 years ago I think it was still new on how it was being used. Now almost 14 years later I started having a few more vertigo attacks, some small only lasting few mins to one other morning at 3am lasting a few hours. I have hopefully found someone here in TX who knows about meniere's and I will bring up Serc to them see if it an option to try again. I'm desperate to try anything to not feel brain fog and always feel as I say drunk.
  6. Megan Henry

    Megan Henry Member

    Oct 5, 2019
    Wish I could take Betahistine. It closes up my airways.
  7. MaryR

    MaryR New Member

    Jul 25, 2019
    Megan... this is just a thought, but are you sure it is the Betahistine you are reacting to and not any of the filler material? I’ve gotten it from a few different compounding pharmacies and the last one I went to said that there seemed to be a lot of extra “filler” like lactose powder (I think) in my previous pills. Just a shot in the dark to look in to...
  8. Megan Henry

    Megan Henry Member

    Oct 5, 2019
    Yep, tried having the compounding pharmacy fill without lactose. Maybe it's another filler. Not sure.
  9. Ben

    Ben New Member

    Feb 23, 2020
    Hey everyone, new to the forums but old hand when it comes to Meniere's! Been suffering a cluster of attacks since late December (ranging from one hour of unsteadiness to 6 hour roller coaster/carousel rides) and have just started histamine 8mg 3 times a day so will report back. Antihistamines just wiped me out with no benefits so hey ho, trying something new. Also, we're having huge drops in air pressure in the UK at the moment to add to the fun...
  10. Liezel

    Liezel New Member

    Feb 14, 2021
    Hi. I'm new here. I've had Meniere's Ds for 10 yrs now. I used to live in the UK and moved here in the US in 2015. I did a lot of searching on the internet on where I could purchase Serc. I have been ordering them online at Northdrugstore.com. There are other websites but seem to have liked this one for some reason. I order Serc 16mgs supply for 3 months. I send them my prescription (upload/email/they call your PCP). It takes up to 21 days to reach me, so they usually call me 4 weeks before I run out. It only costs me $116 including shipping. I hope this helps...
  11. yellowboy

    yellowboy Member

    Jul 11, 2020
    I would like to know why Betahistine - the only thing to keep me functioning AND keeping me from killing myself is not covered in the US by any drug plans ?
  12. Liezel

    Liezel New Member

    Feb 14, 2021
    This is what I found on the web..

    “The brand Serc (betahistine) was approved by the FDA in the early 1970s as vestibular suppressant for Ménière’s disease, but that approval was withdrawn after about 5 years. Primarily, the drug has had issues surrounding its clinical trials and subsequent proof of efficacy. Even though studies have shown betahistine effective against vertigo attacks, most of these studies have been criticized for design flaws. The Cochrane Library concluded in 2001 that “Most trials suggested a reduction of vertigo with betahistine and some suggested a reduction in tinnitus but all these effects may have been caused by bias in the methods. One trial with good methods showed no effect of betahistine on tinnitus compared with placebo in 35 patients. None of the trials showed any effect of betahistine on hearing loss. No serious adverse effects were found with betahistine.”
  13. Jesus

    Jesus New Member

    Mar 31, 2021
    Oviedo, Spain
    Since I take SERC 24mgx2 daily, I only had 1 vertigo episode in two years (when my doctor reduced it at 16x2), so it works great at 24x2 for me.
    I'm amazed that it's not covered in US, is it too expensive without prescription?
  14. No thanks

    No thanks New Member

    Jul 27, 2017
    I purchase it at Universal Drugstore in Canada. I just upload the Rx. I order the entire amount available on the prescription (500) to save on shipping. I take 2 x 16mg daily. Works for me.
    Last edited by a moderator: Apr 16, 2021
    • Creative Creative x 1
  15. Adriana Vogle

    Adriana Vogle New Member

    Apr 5, 2021
    New here to forum and happy I found this.

    I’m my early 40s and diagnosed 19 years ago. No way this is a disease of “older” people. Not to much info around MD when I was diagnosed. Texting to confirm MRIs, balance testing and hearing. First year
    Or two lots of vertigo, nauseas some vomiting. Out of no where most times which made it worse and triggered sign smoking or just being around smoke. Remission verified except for the occasional dizziness with quick head movements. ENT
    Tried watery pill and that’s it. Loss about 40% of hearing in right ear but relies on my left ear so didn’t worry too much but I knew bilateral was a possibility with some MD patients. 19 years in and now I’m bilateral☹️ I thought maybe allergies, infection but more like slowly developing Bilateral MD. This time I’m jumping on it and trying everything. I can’t afford
    To have my left ear get as bad as my right ear.
    Now seeing a Neurologist and who initially put me on water pill. More
    Testing. Mecalizine for vertigo does help thank God.

    Tried on my own the JOH regimen although only for past couple of weeks. Seems to help but still have flair ups.

    Today first time getting steroid shot I’m ear that was effected the most. Only day one so fingers crossed.

    Seems like everyone reacts differently.
    Anyhow after all this to say he did
    call I’m SERC betahistine for me to Keystone pharmacy a compound
    Pharmacy here local and cost me $75 for a
    Months worth.

    Praying this works for me. Have heard a lot of positive things about it. I’ll try anything at this point. Caffeine is a trigger for me well it just increases my tinnitus. I don’t do a lot of sodium.
    • Like Like x 1
  16. RAnthony

    RAnthony New Member

    Feb 16, 2019
    From my treatment blog article: Treating Meniere’s & Its Symptoms
  17. IvanNew

    IvanNew Member

    Jan 18, 2021
    SERC works for many people, but it is not a definitive cure. It just reduces the intensity and frequency of the dizziness, it definitely helps me, now I have dizziness every day, but it almost always lasts seconds or minutes and I never lose my balance. When I stop taking SERC after a few days I have stronger dizziness for hours.

    SERC works in the long term, don't expect quick results, it took me 5 months to notice its effect.
    • Like Like x 2
  18. Jacqui

    Jacqui Member

    Jan 21, 2019
    Athens, Greece
    I really feel for those of you that are paying so much for this medication. Here it is a dirt cheap over the counter product called Antivom available in 8 or 16mg. I guess because we have more ferries than we have bus routes! Wish I could send you all supplies. :(
  19. Adriana Vogle

    Adriana Vogle New Member

    Apr 5, 2021
    I just don’t know for me if I should
    Swap out the water pill for SERC. My ENT said I would have to do one or the other. I have been on the water pull for like 2 months and don’t see too much of a difference. However, seems like the SERC is more for the vertigo which I was hoping it would help with the other symptom to help slow down damage if my good ear which seems to be going bilateral. Hard to decided. Been 1 week of SERC and steroid injection with no changes. The tinnitus is the worst part and the fullness foggy feeling. I can’t just sleep all day. There has to be more too ok help us out there.
  20. dwaynehoover

    dwaynehoover Member

    May 13, 2014
    I tried Betahistine numerous times when I was very sick for years. I tried low and moderate dose and very high dose, it never helped me. Perhaps I didnt take it long enough. I used to look at the UK menieres message board, did not hear many success stories from them although many of them tried it or were on it.

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