http://www.ncbi.nlm.nih.gov/pubmed/26048336 2015 Jun 3. pii: S0378-5955(15)00116-1. doi: 10.1016/j.heares.2015.05.008. [Epub ahead of print] Vasopressin induces endolymphatic hydrops in mouse inner ear, as evaluated with repeated 9.4 T MRI. Degerman E1, In 't Zandt R2, Pålbrink A3, Magnusson M4. Author information Abstract From histopathological specimens, endolymphatic hydrops has been demonstrated in association with inner ear disorders. Recent studies have observed findings suggestive of hydrops using MRI in humans. Previous studies suggest that vasopressin may play a critical role in endolymph homeostasis and may be involved in the development of Ménière's disease. In this study we evaluate the effect of vasopressin administration in vivo in longitudinal studies using two mouse strains. High resolution MRI at 9.4 T in combination with intraperitoneally delivered Gadolinium contrast, was performed before and after chronic subcutaneous administration of vasopressin via mini-osmotic pumps in the same mouse. A development of endolymphatic hydrops over time could be demonstrated in C57BL6 mice (5 mice, 2 and 4 weeks of administration) as well as in CBA/J mice (4 mice, 2 weeks of administration; 6 mice, 3 and 4 weeks of administration). In most C57BL6 mice hydrops developed first after more than 2 weeks while CBA/J mice had an earlier response. These results may suggest an in vivo model for studying endolymphatic hydrops and corroborates the future use of MRI as a tool in the diagnosis and treatment of inner ear diseases, such as Ménière's disease. MRI may also be developed as a critical tool in evaluating inner ear homeostasis in genetically modified mice, to augment the understanding of human disease. This article is part of a Special Issue entitled <IEB Kyoto>. Copyright © 2015 Elsevier B.V. All rights reserved.
I looked up vasopressin: Vasopressin is a man-made form of a hormone called "anti-diuretic hormone" that is normally secreted by the pituitary gland. and get this: (notice the word in red) Vasopressin, also known as arginine vasopressin, antidiuretic hormone, or argipressin, is a neurohypophysial hormone found in most mammals. Its two primary functions are to retain water in the body and to constrict blood vessels. Vasopressin is used to treat diabetes insipidus, which is caused by a lack of this naturally occurring pituitary hormone in the body. Vasopressin is also used to treat or prevent certain conditions of the stomach after surgery or during abdominal x-rays.
so this hormone retains water in our bodies and constrict blood vessels and is related to arginine I would assume, makes sense to me that it would be involved in someone developing Meniere's.
Amazing find Vicki! I'm not sure why no one has posted here but this seems like a very significant connection between Meniere's and argenine. So the question comes what is the opposite of this hormone? It could be something like _______ lysine .
I am a bit surprised to no one commented on this study too. But yes it seems very plausible vasopressin may be involved in developing MM. I wonder if there is a test to see if people with MM have a higher level of this hormone than people w/o MM.
I think this is a great piece of information. But like everything with this disease, if it was as "simple" as arginine than either there is something "different" in how a MM person responds to that than other people (missing piece of puzzle?) or everyone should have it. I think that there are people more susceptible (i.e. allergy or food sensitivity) like you have already found from personal experience. But that is the hard and frustrating thing - to me - about this disease/condition is that it is so darn random. Does not appear to have a common factor; everyone responds to each treatment differently; one can have a two year hiatus and then not doing anything different "bam" it's back. Frustrating to the 'nth degree to me!
Antidiuretic hormone blood test-(which is vasopressin) I wonder of this would tell us anything having MM
the only publication that explained the reason antivirals don't work for everyone is this one, and their conclusion makes sense to me: http://www.sciencedirect.com/science/article/pii/S1568997212000092 The clinical response to antiviral medication indicated that vertigo due to Meniere's disease was relieved in 85–90% of patients. It is not surprising that control of vertigo was not greater than 85–90%, as mutant strains of the herpes virus group would be resistant to the acyclovir class of antivirals. Until newer antivirals are developed, approximately 10% of Meniere's disease patients with vertigo will not be controlled. and if the above is true which seems to be even from the % of our members, the majority seem to be helped with antivirals and or lysine, Dr Gackes success rate matches this too and other studies as well, then if vasopressin is involved whatever way with arginine which promotes the HSV and retaining fluid and constricting blood vessels, it explains it for everyone.