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Sound Pharmaceuticals announces completion of patient enrollment in the Phase 2b Meniere's Disease c

Discussion in 'Your Living Room' started by jkc, Mar 12, 2019.

  1. Mac

    Mac Active Member

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    I was in both trials. I have some previous posts on it.

    It is an anti inflammatory. It essentially does what steroids cant do in the inner ear. It reduces inflammation thus lowering symptoms. It is a pill that somehow it gets to the inner ear. As we all know...steroids currently can't.

    I am looking forward to seeing the Phase 2 numbers. Phase 1 were good.
     
    • Informative Informative x 3
  2. Jacqui

    Jacqui Member

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    Athens, Greece
  3. Mac

    Mac Active Member

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    • Informative Informative x 2
  4. Irishstu

    Irishstu Member

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    Really great news. A lot of scientific progress on this front, thankfully.
     
    • Like Like x 1
  5. Fisherman42

    Fisherman42 Active Member

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    This could be a dream come true if it really works.
     
    • Agree Agree x 1
  6. Mac

    Mac Active Member

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  7. Mindosa

    Mindosa Member

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    We all impatiently are waiting for SPI-1005 (Ebselen) to be approved by FDA to treat MD symptoms, but maybe NOW the solution is already available and it’s cheap and available, unlike Ebselen, also safe and you don’t need the prescription!

    So what I had found in the internet:

    SPI-1005 (Ebselen) mimics and induces glutathione peroxidase. NAC is also glutathione precursor.

    Ebselen and NAC, both potentiate the glutathione peroxidase pathway. These two compounds were capable of increasing endothelial glutathione levels.

    This efficient mechanism of action allows SPI-1005 (Ebselen) to work at low oral doses, unlike antioxidants such as n-acetylcysteine (NAC).

    Both SPI-1005 (Ebselen) and NAC protects ophthalmic and otological structures from oxidative damage.

    So, if I am right, SPI-1005 and NAC works in very similar ways. Only SPI-1005 (Ebselen) is more efficient and needed low oral doses to reach the effect comparing with NAC.

    What are your thoughts?
     
  8. Mindosa

    Mindosa Member

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  9. jose suarez

    jose suarez Member

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    Is not available
     
  10. jose suarez

    jose suarez Member

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    I get nac and pine bark
     
  11. Mindosa

    Mindosa Member

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    While we are waiting for Ebselen to be approved for the Meniere's disease and hoping that treatment will be available for everyone in terms of price and will be effective, my proposal is to find alternatives with which we can mimic Ebselen’s properties.
    More about this here:
    Has anyone tried to get Ebselen (SPI-1005) online?
     

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