Sound Pharmaceuticals announces completion of patient enrollment in the Phase 2b Meniere's Disease clinical trial
I was in both trials. I have some previous posts on it. It is an anti inflammatory. It essentially does what steroids cant do in the inner ear. It reduces inflammation thus lowering symptoms. It is a pill that somehow it gets to the inner ear. As we all know...steroids currently can't. I am looking forward to seeing the Phase 2 numbers. Phase 1 were good.
What an interesting drug SPI-1005 is based on! So many disorders and illnesses it may treat; https://blogs.sciencemag.org/pipeli...ss-of-ebselen?r3f_986=https://www.google.com/ Also mentioned is that the glutathione peroxidase activity that it stimulates is low in MS patients too. Keep us informed Mac!
more good news... FDA grants Fast Track Designation for SPI-1005 in the Treatment of Meniere's Disease Have a great weekend!! Mac
I was in both of these trials years ago...This drug will be helpful when it gets released. Very cool to see this news break. It may help Covid patients as well. Dr. Kil is doing great things in Seattle. Sound Pharmaceuticals files IND to test SPI-1005 in Phase 2 COVID-19 trials Have a great day. Mac
We all impatiently are waiting for SPI-1005 (Ebselen) to be approved by FDA to treat MD symptoms, but maybe NOW the solution is already available and it’s cheap and available, unlike Ebselen, also safe and you don’t need the prescription! So what I had found in the internet: SPI-1005 (Ebselen) mimics and induces glutathione peroxidase. NAC is also glutathione precursor. Ebselen and NAC, both potentiate the glutathione peroxidase pathway. These two compounds were capable of increasing endothelial glutathione levels. This efficient mechanism of action allows SPI-1005 (Ebselen) to work at low oral doses, unlike antioxidants such as n-acetylcysteine (NAC). Both SPI-1005 (Ebselen) and NAC protects ophthalmic and otological structures from oxidative damage. So, if I am right, SPI-1005 and NAC works in very similar ways. Only SPI-1005 (Ebselen) is more efficient and needed low oral doses to reach the effect comparing with NAC. What are your thoughts?
Decided to check what prices are now for the Ebselen (SPI-1005) and what treatment cost for MD we could expect if Sound Pharmaceuticals study for Meniere's disease will succeed. Has anyone tried to get Ebselen (SPI-1005) online?
While we are waiting for Ebselen to be approved for the Meniere's disease and hoping that treatment will be available for everyone in terms of price and will be effective, my proposal is to find alternatives with which we can mimic Ebselen’s properties. More about this here: Has anyone tried to get Ebselen (SPI-1005) online?