SPI-1005 Enters Phase 3 Trials, on fast track with FDA - Sept. 2019

Ledwards · Sep 1, 2020

Aaron said: ↑

I crossed this same NAC thought process upon researching Ebselen, and added NAC to my regimen several months ago because of this. I also added a few other anti-oxidants (grapeseed extract, pine bark extract, turmeric, selenium) and re-introduced L-Lysine so hard to say what has produced my favorable results. I will say my vertigo is more under control now than its ever been. It is is so minor and infrequent that I often forget about it (unless I get into a moving vehicle) -- it is usually a 0-3 on a 10 point scale. The fluctuating tinnitus is still there, although quieter most of the time that I can forget about it when concentrating on tasks.

I've spent a lot of time researching the correlation between oxidative stress and Meniere's, and I've wondered whether high oxidative stress in my body is the underlying cause of my Meniere's -- and whether this high oxidative stress environment has causes both inflammation and possibly also viruses to more easily attack my ear. I read a study that showed viruses thrive in conditions of high oxidative stress because the body's immune system is suppressed (eg due to glutathione being depleted). This is important because glutathione is not only the body's primary antioxidant but also has resultant antiviral activity. NAC is the limiting precursor to glutathione so taking NAC should boost glutathione levels (much more than taking glutathione supplement directly which is inconclusive if it works).

This is a great video on how the body uses Glutathione/NAC and how it relates to COVID. There is even a shotout to a study which mentions Meniere's Disease @ 12:17 which states:
"Asher and Guilford performed a review of the literature from 1980 to 2016 on the role that oxidative stress and GSH play in the ear, nose and throat (ENT) conditions. The authors concluded that many ENT conditions such as rhinitis, allergic rhinitis, chronic rhinosinusitis (CRS), CRS with polyps, otitis media with effusion, chronic otitis media (COM), COM and cholesteatoma, tympanic membrane sclerosis, tonsillitis, Meniere disease, laryngeal conditions, and chronic cough are associated with oxidative stress and decreased GSH, both locally in the affected tissues and systemically. They also suggested that the oxidative stress related to those conditions may be due to depletion of GSH"

The question that has been on my mind is, which came first... the viral load or the high oxidative stress environment?
Click to expand...

how much of the extracts do you take? And can I just get NAC from like Vitacost?

Mindosa · Nov 8, 2020

Decided to check what prices are now for the Ebselen (SPI-1005) and what treatment cost for MD we could expect if Sound Pharmaceuticals study for Meniere's disease will succeed.

Has anyone tried to get Ebselen (SPI-1005) online?

jose suarez · Nov 8, 2020

How can I buy Nac? Under what name I can get it

jose suarez · Nov 8, 2020

I try to get it on Amazon but it said currently unavailable

Mindosa · Nov 21, 2020

While we are waiting for Ebselen to be approved for the Meniere's disease and hoping that treatment will be available for everyone in terms of price and will be effective, my proposal is to find alternatives with which we can mimic Ebselen’s properties.
More about this here:
Has anyone tried to get Ebselen (SPI-1005) online?

jose suarez · Nov 24, 2020

I hope that they are working in that. I need it rushh

jose suarez · Nov 24, 2020

I bought the NAC but im not taken yet. My cocktail of pills are
Pine bark extract
Ginkgo biloba
Fucoidan
L-lysine
Sterois and sterolins
Serrapeptase
Vit c
Roobois tea
Mint tea
Turmerix

Mindosa · Dec 28, 2020

Mindosa said: ↑

NAC is also glutathione precursor
Click to expand...

Here is more info about the NAC. For increasing glutathione levels in your body you may need not a NAC or glutathione supplements, but something else entirely different. More about this is here:

Has anyone tried to get Ebselen (SPI-1005) online?

IvanNew · Jan 30, 2021

They have recruited and started a new clinical trial, this time with quite a few controls and 200 participants. The bad news is that it does not end until December 2022, the good news that if they do this test is that it must have obtained good results in the previous test that I already thought was the last.

SPI-1005 for the Treatment of Meniere's Disease - Full Text View - ClinicalTrials.gov

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SPI-1005 Enters Phase 3 Trials, on fast track with FDA - Sept. 2019

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